Crash Course Hematology and Immunology ebook free download

 

Crash Course Hematology and Immunology ebook free download

Crash Course Hematology and Immunology ebook free download

Crash Course Hematology and Immunology ebook free download

Crash Course Hematology and Immunology ebook free download

Preface

Hematology and immunology are two words that are certain to strike dread into most therapeutic understudies. They both have the notoriety of being complex, lab-based specialities that lose their significance once we achieve ‘this present reality’.

Truly, learning of both hematology and immunology are colossally imperative for the practice of all specialities, both clinical and lab-based. This incorporates points running from pallor, which is experienced by all clinicians; to non-steroidal calming medications, which are recommended by junior specialists all through the world.

In Crash Course: Hematology and Immunology we have tried to show the sound physiological priniciples that support the new advancements in both specialities. In this manner, furnishing the peruser with the establishments expected to handle the medicines that will rise after the production of this book. We have additionally fused clinical situations to fortify the learning and comprehension of the essential exploratory priniciples. We trust you appreciate hematology also, immunology.

Contents

1. Principles of haematology . . . . . . . . . 1
Overview of haematology—the cell
lines . . . . . . . . . . . . . . . . . . . 1
Haemopoiesis and its regulation. . . . . . . 2
Bone marrow . . . . . . . . . . . . . . . 3
The spleen. . . . . . . . . . . . . . . . . 4
2. Red blood cells and haemoglobin. . . . . . 9
Structure and function of erythrocytes . . . . 9
Erythropoiesis . . . . . . . . . . . . . . . 9
Iron and haem metabolism . . . . . . . . 12
Haemoglobin . . . . . . . . . . . . . . 15
The cytoskeleton of the red cell . . . . . . 17
Metabolism of red cells . . . . . . . . . . 18
Full blood count and reticulocyte
count . . . . . . . . . . . . . . . . . 19
Peripheral blood film . . . . . . . . . . . 20
3. Red blood cell disorders . . . . . . . . . 23
Anaemia caused by haematinic
deficiency . . . . . . . . . . . . . . . 23
Anaemia of chronic disease . . . . . . . . 24
Anaemia due to increased red-cell
destruction (haemolytic anaemias) . . . . 27
Haemoglobinopathies . . . . . . . . . . 31
Investigation of haemoglobinopathies . . . 33
Anaemia due to blood loss . . . . . . . . 34
Marrow defects . . . . . . . . . . . . . 34
Polycythaemia (erythrocytosis) . . . . . . 35
4. White blood cells . . . . . . . . . . . . 37
Structure and function of the white
blood cells . . . . . . . . . . . . . . . 37
Differentiation of white cells . . . . . . . 39
Differential white count . . . . . . . . . 40
Reactive proliferation of white cells . . . . 42
Leucopenia . . . . . . . . . . . . . . . 42
5. Haematological malignancies. . . . . . . 45
Introduction to haematological
malignancies . . . . . . . . . . . . . . 45
Investigations of haematological
malignancies . . . . . . . . . . . . . . 54
6. Haemostasis. . . . . . . . . . . . . . . 57
Platelets and blood coagulation . . . . . . 57
Antiplatelet drugs . . . . . . . . . . . . 59
Platelet disorders . . . . . . . . . . . . . 60
The coagulation cascade . . . . . . . . . 63
Clotting tests . . . . . . . . . . . . . . 66
Clotting factor disorders . . . . . . . . . 66
Thrombosis . . . . . . . . . . . . . . . 69
7. Blood transfusion . . . . . . . . . . . . 73
Introduction in blood products . . . . . . 73
Indications for red cell transfusion . . . . . 73
Red-cell antigens. . . . . . . . . . . . . 74
Cross-matching and blood transfusion . . . 75
8. Principles of immunology . . . . . . . . 79
An overview of immunology . . . . . . . 79
9. The innate immune system . . . . . . . . 83
Barriers to infection . . . . . . . . . . . 83
Cells of innate immunity . . . . . . . . . 83
Soluble proteins . . . . . . . . . . . . . 86
Innate immune system pattern
recognition molecules . . . . . . . . . . 90
10. The adaptive immune system. . . . . . . 91
The immunoglobulin domain . . . . . . . 91
Generation of antigen receptor diversity . . 94
Humoral immunity . . . . . . . . . . . . 97
Cell-mediated immunity . . . . . . . . . 102
11. The functioning immune system . . . . . 109
Response to tissue damage . . . . . . . . 109
Immune response to pathogens . . . . . . 112
12. Immune dysfunction . . . . . . . . . . . 117
Hypersensitivity . . . . . . . . . . . . . 117
Allergy . . . . . . . . . . . . . . . . . 120
Autoimmunity . . . . . . . . . . . . . . 122
Immune deficiency . . . . . . . . . . . . 127
Investigation of immune function . . . . . 132
13. Medical intervention . . . . . . . . . . . 135
Immunization . . . . . . . . . . . . . . 135
Transplantation . . . . . . . . . . . . . 137
Anti-inflammatory drugs . . . . . . . . . 138
Multiple Choice Questions (MCQs). . . . . . 143
Extended Matching Questions . . . . . . . . 153
MCQ Answers . . . . . . . . . . . . . . . . 161
EMQ Answers . . . . . . . . . . . . . . . . 167
Glossary . . . . . . . . . . . . . . . . . . . 173
Index . . . . . . . . . . . . . . . . . . . . 175

Crash Course Hematology and Immunology ebook free download

Crash Course Hematology and Immunology ebook free download

Crash Course Hematology and Immunology ebook free download

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